Anti-GPC-1 Antibody for Therapeutic & Imaging Applications.

Our patented antibodies target Glypican-1 (GPC-1), a protein overexpressed in prostate, pancreatic, bladder, glioblastoma, esophageal, lung and ovarian cancers. Importantly, there is no antibody reactivity in normal tissues. We are examining multiple mechanisms of action including:

– Radioimmunotherapy
– Bispecific antibodies
– Immune cell engagement and activation

We have now completed a First-in-Human trial in Australia using Miltuximab®, our anti-GPC-1 monoclonal antibody (ANZCTR registry). The trial dosed 12 patients and no drug-related adverse events were observed.

We are currently planning a follow up Phase-1b theranostic study of at least 12 more patients. Candidates will be selected by PET imaging using 89Zr-Miltuximab® and then dosed with the therapeutic version of Miltuximab® (177Lu-Miltuximab®).  

Glytuzumab® refers to the humanized version of Miltuximab® and also targets human GPC-1. The Glytuzumab® program is currently undergoing Lead Optimization and Lead Selection. Several humanized leads have been generated with similar binding affinities to that of the parent molecule Miltuximab®. The final Glytuzumab® lead selected will be taken forward from cell line development through to large scale GMP production for future clinical trials.

Achievements

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2021

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Commenced production of GMP-Miltuximab® for Phase-1b clinical trial 

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2020

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Carina Biotech and GlyTherix enter into CAR-T partnership 

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GlyTherix’s Miltuximab® antibody becomes the flagship project for a Co-operative Research Centre Project Grant 

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2019

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Preclinical work now completed for upcoming Phase I clinical trial in GPC-1 expressing solid tumours. This will use Miltuximab® labelled with either 89Zirconium for imaging or 177Lutetium for therapy

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First-in-Human clinical trial of Miltuximab® labelled with 67Gallium for imaging met primary endpoint of safety in all 12 patients

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Antibody composition of matter patents granted EU and US

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2018

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Completion of accrual for clinical study of Miltuximab® in prostate, bladder and pancreatic cancers

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2017

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The second stage of pioneering MILGa clinical trial of Miltuximab®

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2016

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Commenced First-In-Human trial of Miltuximab® 

2015 Eureka Prize

Excellence in Interdisciplinary Scientific Research

Major Australian prize for innovation awarded to our CEO, Brad Walsh, and university collaborators.

Find Out More Information

  • About our groundbreaking first-in-human trial of our novel cancer target >More
  • About how your company and Glytherix could partner to deliver better cancer therapeutics >More 

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